Correlation of MRI biomarkers with tumor necrosis in Hras5 tumor xenograft in athymic rats.

@article{Bradley2007CorrelationOM,
  title={Correlation of MRI biomarkers with tumor necrosis in Hras5 tumor xenograft in athymic rats.},
  author={Daniel P Bradley and Jean J L Tessier and Susan Elizabeth Ashton and John C. Waterton and Zena Wilson and Philip L. Worthington and Anderson Joseph AstraZeneca R D Alderley Ryan},
  journal={Neoplasia},
  year={2007},
  volume={9 5},
  pages={382-91}
}
Magnetic resonance imaging (MRI) can measure the effects of therapies targeting the tumor vasculature and has demonstrated that vascular-damaging agents (VDA) induce acute vascular shutdown in tumors in human and animal models. However, at subtherapeutic doses, blood flow may recover before the induction of significant levels of necrosis. We present the relationship between changes in MRI biomarkers and tumor necrosis. Multiple MRI measurements were taken at 4.7 T in athymic rats (n = 24… CONTINUE READING

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