Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells
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@article{Dixon2019CorrelationOI,
  title={Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells
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  author={Brianne N Dixon and Ryan J. Daley and Larry W. Buie and Meier Hsu and Jae Hong Park and Renier J Brentjens and Terence J. Purdon and Sheron Latcha},
  journal={Clinical nephrology},
  year={2019}
}
BACKGROUND Various studies have demonstrated that interleukin-6 (IL-6) activates the central magnocellular arginine vasopressin (AVP)-secreting neurons in the brain to produce non-osmotic, non-volume-mediated increases in AVP. The most common toxicity of CD19+ chimeric antigen receptor (CAR) T-cells is cytokine release syndrome, which is related to increased levels of IL-6. This study will evaluate the correlation of IL-6 levels with hyponatremia in patients receiving CD19+ CAR T-cells… CONTINUE READING