Corpus ID: 52258401

Correlation of HSP 70 , P 53 and Bmi-1 in hepatitis , cirrhosis and hepatocellular carcinoma

@inproceedings{Liu2016CorrelationOH,
  title={Correlation of HSP 70 , P 53 and Bmi-1 in hepatitis , cirrhosis and hepatocellular carcinoma},
  author={Ming Liu and Na Miao and Jun-zhi Li and Zhiqiang Wang and Zhing wang and Mengyan Li and Wei Sang and Liping Su and Qiaoxin and Li and Xiaoli Shi},
  year={2016}
}
Objective: To investigate the correlation of HSP70, P53 and Bmi-1 in hepatitis, cirrhosis and hepatocellular carcinoma patients. Methods: Hepatitis (30 cases), cirrhosis (30 cases), early stage HCC (30 cases), and advanced stage HCC (80 cases) patients were recruited in this study, and we used immunohistochemistry S-P method to detect the protein expression levels of HSP70, P53 and Bmi-1, which were then correlated with clinical pathological parameters. Results: (1) HSP70, P53 and Bmi 1… Expand

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References

SHOWING 1-10 OF 13 REFERENCES
Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
TLDR
The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC. Expand
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
TLDR
Results suggested that modulation of Bmi-1 protein might be involved in human colorectal carcinogenesis by repressing the INK4a/ARF proteins. Expand
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
TLDR
The overexpression of polycomb-group proteins Bmi1 and EZH2 is associated with the malignant progression of HCC, thereby reflecting the aggressive biological behavior in HCC and HC–CC. Expand
Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma
TLDR
These data within a prospective study establish the clinical usefulness of this panel of markers for the diagnosis of early HCC, however, the panel only slightly increases the diagnostic accuracy in an expert setting. Expand
Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.
TLDR
It is reported that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Expand
Expression of HSP70 and JNK-related proteins in human liver cancer: Potential effects on clinical outcome.
  • H. Li, C. Sui, F. Kong, H. Zhang, J. Liu, M. Dong
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2007
TLDR
The balance between heat shock protein70 and c-Jun N-terminal kinase-related protein may increase the stability of liver cancer cells in stress and be an indicator of malignant potential in liver carcinoma. Expand
p53 Stabilization Induces Cell Growth Inhibition and Affects IGF2 Pathway in Response to Radiotherapy in Adrenocortical Cancer Cells
TLDR
The role of p53 in response to radiation of ACC cell lines is highlighted, suggesting its importance as a predictive factor for radiotherapy in malignant adrenocortical tumours cases. Expand
Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24.
TLDR
It is demonstrated that Twist2 augments liver cancer stem-like cell self-renewal in a CD24-dependent manner and provides a potential therapeutic approach to target cancer stem cells in HCCs. Expand
Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment
TLDR
The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal L SM values, and the cumulative exposure duration of boosted-PIs and γ-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively. Expand
Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
TLDR
It is demonstrated that the mortalin–p53 interaction exists in cancer cells that are either physiologically stressed (frequently associated with p53 mutations) or treated with stress-inducing chemicals. Expand
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