Correlation of HLA and thyroid antibodies with clinical course of thyrotoxicosis treated with antithyroid drugs.

@article{Irvine1977CorrelationOH,
  title={Correlation of HLA and thyroid antibodies with clinical course of thyrotoxicosis treated with antithyroid drugs.},
  author={W. J. Irvine and Robert S. Gray and Peter J. Morris and Alan Ting},
  journal={Lancet},
  year={1977},
  volume={2 8044},
  pages={898-900}
}
The prevalence of HLA-B8 in thyrotoxic (Graves' disease) patients who relapsed after withdrawal of antithyroid drugs was high (69%) compared with that in patients who remained in remission (40%) and in healthy controls (28%). B8-positive patients were 1-8 times more likely to relapse after withdrawal of drug therapy than B8-negative patients. The… CONTINUE READING