• Corpus ID: 212442849

Correlation of Fibrinolysis Marker of Plasma Plasminogen Activator Inhibitor type-1 and Oxidative Stress Parameters in Occurrence and Progression of coronary Artery Disease

@inproceedings{khakikhatibi2015CorrelationOF,
  title={Correlation of Fibrinolysis Marker of Plasma Plasminogen Activator Inhibitor type-1 and Oxidative Stress Parameters in Occurrence and Progression of coronary Artery Disease},
  author={fatemeh khaki-khatibi and N. Mahmoodi and Sakhavat Abolhasani and Reza Pahlevan Gharebaba},
  year={2015}
}

• F. khaki-khatibi, N. Mahmoodi, +1 author Reza Pahlevan Gharebaba
• Published 2015
• Biology

Coronary artery disease (CAD) is a leading cause of death of women and men worldwide. Fibrinolysis and oxidative stress may be considered as novel risk factors of coronary artery disease (CAD). In the present study we made an attempt to evaluate the association between plasminogen activator inhibitor type-1(PAI-1) as a fibrinolysis marker and oxidative stress status parameters [malonaldehyde (MDA), and oxidized low density lipoprotein ( ox-LDL )] and also their association with progression of CAD. Besides general risk factors, PAI-1, MDA and ox-LDL were compared between 160 angiographically diagnosed CAD patients and 20 age/sex matched healthy subjects. Furthermore, according to the number of occluded vessels CAD patients subdivided into 4 groups and association between all risk factors and severity of CAD was examined. Using multiple regression analysis independent correlation of MDA and ox-LDL with PAI-1 was revealed. Our findings showed that not only the levels of PAI-1 and oxidative stress parameters in CAD patients are significantly higher than controls, but there are a significant difference between the levels of these parameter among subgroups of patients who were divided based on the progression of CAD. According to our statistical analysis, an independent correlation was revealed between the PAI-1 and oxidative stress parameters. Findings from this study suggest that PAI-1, and oxidative stress parameters (ox-LDL and MDA) are mutually involved in the occurrence and progression of CAD and these parameters may be useful in diagnosis and monitoring of CAD in patients.