• Corpus ID: 212442849

Correlation of Fibrinolysis Marker of Plasma Plasminogen Activator Inhibitor type-1 and Oxidative Stress Parameters in Occurrence and Progression of coronary Artery Disease

@inproceedings{khakikhatibi2015CorrelationOF,
  title={Correlation of Fibrinolysis Marker of Plasma Plasminogen Activator Inhibitor type-1 and Oxidative Stress Parameters in Occurrence and Progression of coronary Artery Disease},
  author={fatemeh khaki-khatibi and N. Mahmoodi and Sakhavat Abolhasani and Reza Pahlevan Gharebaba},
  year={2015}
}
Coronary artery disease (CAD) is a leading cause of death of women and men worldwide. Fibrinolysis and oxidative stress may be considered as novel risk factors of coronary artery disease (CAD). In the present study we made an attempt to evaluate the association between plasminogen activator inhibitor type-1(PAI-1) as a fibrinolysis marker and oxidative stress status parameters [malonaldehyde (MDA), and oxidized low density lipoprotein ( ox-LDL )] and also their association with progression of… 
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References

SHOWING 1-10 OF 65 REFERENCES

Elevated plasma plasminogen activator inhibitor type-1 is an independent predictor of coronary microvascular dysfunction in hypertension.

Elevated plasma PAI-1 activity was independently associated with coronary microvascular dysfunction, which suggests that plasmaPAI- 1 activity is an important clue linking hypofibrinolysis to the development of atherosclerosis.

Prognostic value of plasma fibrinolysis activation markers in cardiovascular disease.

  • Diana A Gorog
  • Medicine, Biology
    Journal of the American College of Cardiology
  • 2010

Concentration of endogenous tPA antigen in coronary artery disease: relation to thrombotic events, aspirin treatment, hyperlipidemia, and multivessel disease.

It is suggested that thrombus formation and simultaneous endothelial cell activation might be major determinants for tPA antigen concentration in CAD, and low-dose aspirin rather would decrease the likelihood of thrombotic events.

Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study.

The hypothesis that thrombosis and fibrinolysis play a role at the early stage of the atherosclerotic process is supported.

High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor.

Plasma levels of PAI-1, tissue-type plasminogen activator (tPA), von Willebrand factor (vWF), and vWF are associated with subsequent development of a first acute myocardial infarction and this relation was found in both men and women.

Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metoprolol. Results from the Angina Prognosis study in Stockholm.

Plasma TPA-ag levels at rest, and among male patients PAI-1 activity as well, independently predict subsequent CV death or MI in patients with stable angina pectoris.

Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease

  • V. RaoR. Kiran
  • Medicine
    Journal of cardiovascular disease research
  • 2011
It is suggested that increased oxidative stress and abnormal lipid profile are two independent risk factors in the pathomechanism of atherogenesis.

Progression of coronary artery disease in young male post-infarction patients is linked to disturbances of carbohydrate and lipoprotein metabolism and to impaired fibrinolytic function.

Disturbances in carbohydrate and lipoprotein metabolism and impaired fibrinolytic function are associated with progression of coronary artery disease in young male post-infarction patients.

THE RELATIONSHIP BETWEEN OXIDATIVE STRESS, NITRIC OXIDE, AND CORONARY ARTERY DISEASE

The high MDA levels among all patients with CAD demonstrate a strong relationship between the oxidative stress and the coronary artery disease, and no significant relationship was determined between MDA and NO levels.
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