Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia.

Abstract

The carcinostatic activity has been studied for fatty acids of diverse species but scarcely for fatty alcohols. Three unsaturated fatty alcohols at 35-50 microM inhibited DNA synthesis and the proliferation of tumor cells by a combination with hyperthermia to greater extents in the order: oleyl (C18:1)-> linoleyl (C18:2)-> alpha-linolenyl (C18:3) alcohol… (More)

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@article{Takada2001CorrelationOD, title={Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia.}, author={Yasutsugu Takada and Ken Kageyama and Ryo Yamada and Yasuto Onoyama and Takayuki Nakajima and Masako N. Hosono and Nobuhiko Miwa}, journal={Oncology reports}, year={2001}, volume={8 3}, pages={547-51} }