Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.

@article{Chou2003CorrelationOD,
  title={Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.},
  author={Ming W. Chou and Jian Yan and Jasyl Nichols and Qingsu Xia and Frederick A Beland and P Chan and Peter P Fu},
  journal={Cancer letters},
  year={2003},
  volume={193 2},
  pages={119-25}
}
Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in male and female F344 rats and male B6C3F(1) mice. We previously reported that eight dehydroretronecine (DHR)-derived DNA adducts were formed in liver DNA of rats treated with riddelliine. In order to examine the relationship between DNA adduct levels and the incidence of hemangiosarcomas, we have measured DHR-derived DNA adduct levels in purified rat and mouse liver endothelial cells, the cells of… CONTINUE READING

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