Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia

@article{Yoshida2009CorrelationOC,
  title={Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia},
  author={Nao Yoshida and Hiroshi Yagasaki and Yinyan Xu and Kazuyuki Matsuda and Ayami Yoshimi and Yoshiyuki Takahashi and Asahito Hama and Nobuhiro Nishio and Hideki Muramatsu and Nobuhiro Watanabe and Kimikazu Matsumoto and Koji Kato and Junichi Ueyama and Hiroko Inada and H Goto and Miharu Yabe and Kazuko Kudo and Junichi Mimaya and Akira Kikuchi and Atsushi Manabe and Kenichi Koike and Seiji Kojima},
  journal={Pediatric Research},
  year={2009},
  volume={65},
  pages={334-340}
}
Mutations in RAS, neurofibromatosis type 1 (NF1), and PTPN11, constituents of the granulocyte-macrophage colony-stimulating factor signaling pathway, have been recognized in patients with juvenile myelomonocytic leukemia (JMML). We assessed 71 children with JMML for NRAS, KRAS, and PTPN11 mutations and evaluated their clinical significance. Of the 71 patients, three had been clinically diagnosed with neurofibromatosis type 1, and PTPN11 and NRAS/KRAS mutations were found in 32 (45%) and 13 (18… CONTINUE READING