Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy

@inproceedings{Zhang2014CorrelationOC,
  title={Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy},
  author={Hao Zhang and Xu Cai and Bin Yi and Jing Huang and Jianwen Wang and Jian Sun},
  booktitle={Molecular medicine reports},
  year={2014}
}
Increasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) and its complications. Previous studies conducted by our group have indicated that high glucose levels may induce the demethylation process of the connective tissue growth factor (CTGF) gene promoter and increase the expression of CTGF in human glomerular mesangial cells. Based on these findings, the aim of the present study was to investigate the methylation level of genomic… CONTINUE READING

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CITES BACKGROUND
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References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Clinical significance of inflammatory and fibrogenic cytokines in diabetic nephropathy

HO El Mesallamy, HH Ahmed, AA Bassyouni, AS Ahmed
  • Clin Biochem
  • 2012
VIEW 1 EXCERPT

Epigenetics in diabetic kidney disease.

  • Journal of the American Society of Nephrology : JASN
  • 2011

[High glucose induce the demethylation of CTGF promoter and gene expression].

Bin Yi, Hao Zhang, +3 authors Yan Liu
  • Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
  • 2011
VIEW 2 EXCERPTS

Complications of type 1 diabetes.

  • Endocrinology and metabolism clinics of North America
  • 2010
VIEW 1 EXCERPT