Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig.

@article{Dennis1993CorrelationO,
  title={Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig.},
  author={Donn M. Dennis and John C. Shryock and Luiz Belardinelli},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 2},
  pages={543-50}
}
This study was designed to develop a high-performance liquid chromatography-based analytical method to measure the blood concentration of (-)N6-phenylisopropyladenosine (R-PIA) in order to correlate such levels with cardiac responses, and to determine the pharmacokinetics of R-PIA. Experiments were carried out in anesthetized adult guinea pigs instrumented for measurement of the surface ECG. After i.v. (50 micrograms/kg; n = 9) or i.p. (3.5 mg/kg; n = 5) administration of R-PIA, the atrial rate… CONTINUE READING