[Correlation between urinary catecholamines dosage and apnea-hypopnea index in a hypertension population: pilot study].

Abstract

AIMS Sleep disorders like obstructive sleep apnea in adults are associated with increased sympathetic activity, which induced high blood pressure and could be associated with resistant hypertension. Some studies have demonstrated that high urinary catecholamine levels in obstructive sleep apnea patients may be decreased with continuous positive airway pressure therapy. However, very few studies have demonstrated a correlation between apnea-hypopnea index and urinary catecholamine levels in hypertension patients. METHODS In this pilot study, 20 hypertensive patients referred for hypertension work-up including night-time polygraphy and 24h urinary catecholamine dosage were included. RESULTS Mean age was 51±11 years (30-76), 68% were males. Diagnosis of obstructive sleep apnea was confirmed in 13 patients at the end of the work-up. Mean apnea-hypopnea index was 14±9 (2-32). The only urinary catecholamine parameter significantly increased in patients with obstructive sleep apnea was 24h urinary normetanephrine (1931±1285 vs 869±293nmol/24h; P<0.05). However, this difference was not significant when this parameter was adjusted to 24h urinary creatinine. We observed a significant positive correlation between AHI and 24h urinary normetanephine (r=0.486; P=0.035). CONCLUSION This pilot study confirms an isolated elevation of 24h urinary normetanephrine in hypertensive patients with obstructive sleep apnea and shows a significant correlation between sleep disorders expressed by apnea-hypopnea index and urinary catecholamines excretion.

DOI: 10.1016/j.ancard.2014.05.004

Cite this paper

@article{LopezSublet2014CorrelationBU, title={[Correlation between urinary catecholamines dosage and apnea-hypopnea index in a hypertension population: pilot study].}, author={Marilucy Lopez-Sublet and Sylvain Le Jeune and B{\'e}n{\'e}dicte Giroux-Leprieur and D Agnoletti and Robin Dh{\^o}te and J J Mourad}, journal={Annales de cardiologie et d'angéiologie}, year={2014}, volume={63 3}, pages={140-4} }