Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma

@article{Tomizawa1999CorrelationBT,
  title={Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma},
  author={Yoshio Tomizawa and Takashi Kohno and Takeshi Fujita and Masaharu Kiyama and Ryusei Saito and Masayuki Noguchi and Yoshihiro Matsuno and Setsuo Hirohashi and Naohito Yamaguchi and Takashi Nakajima and Jun Yokota},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1007-1014}
}
The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique… CONTINUE READING