Correlation between the inhibition of cell growth by accumulated polyamines and the decrease of magnesium and ATP.

@article{He1993CorrelationBT,
  title={Correlation between the inhibition of cell growth by accumulated polyamines and the decrease of magnesium and ATP.},
  author={Yuan He and Keiko Kashiwagi and Junichi Fukuchi and Kayoko Terao and Akira Shirahata and Kazuei Igarashi},
  journal={European journal of biochemistry},
  year={1993},
  volume={217 1},
  pages={89-96}
}
The mechanism of the antiproliferation effect of spermidine and spermine was studied using a cell culture system of mouse FM3A cells. The addition of either 10 mM spermidine or 2 mM spermine to the growth medium containing 0.9 mM Mg2+ greatly inhibited cell growth (more than 90%). A decrease in the Mg2+ concentration to 50 microM in the growth medium, but without the polyamine addition, did not influence cell growth. However, the concentrations of spermidine and spermine necessary for the… CONTINUE READING

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