Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells

@inproceedings{Li2008CorrelationBT,
  title={Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells},
  author={Zhu Li and Zhang Lai and Ke Ya and Du Fang and Y. W. Ho and Yang Lei and Qian Zhong Ming},
  booktitle={Journal of cellular and molecular medicine},
  year={2008}
}
Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia-inducible genes. Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions. In addition, in the 5' regulatory region of human DMT1 (between -412 and -570), there are two motifs (CCAAAGTGCTGGG) that are similar to hypoxia-inducible factor-1 (HIF-1) binding sites. It was therefore speculated that DMT1 might also be a hypoxia-inducible gene… CONTINUE READING

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Hypoxia-inducible factor as a physiological regulator

  • PH Maxwell
  • Exp Physiol
  • 2005
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