Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.

@article{Rubin1988CorrelationBT,
  title={Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.},
  author={Berish Y. Rubin and L. J. Smith and Gary R. Hellermann and Ruth M Lunn and N. K. Richardson and Sylvia L. Anderson},
  journal={Cancer research},
  year={1988},
  volume={48 21},
  pages={6006-10}
}
The treatment of cells sensitive to the anticellular effect of tumor necrosis factor (TNF) with TNF results in a degradation of their cellular DNA into DNA fragments that are multiples of 200 base pairs. TNF treatment of cells resistant to the anticellular effect of TNF, but bearing receptors for TNF, fails to result in any DNA fragmentation. Incubation conditions, such as temperature, the presence of metabolic inhibitors or amino acid deprivation, that modulate the effectiveness of TNF or… CONTINUE READING

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