Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin.

@article{Herman1999CorrelationBS,
  title={Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin.},
  author={Eugene H. Herman and Jun Zhang and Steven E. Lipshultz and Nader Rifai and Douglas P. Chadwick and K Takeda and Zhao Xiang Yu and V{\'i}ctor J. Ferrans},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1999},
  volume={17 7},
  pages={
          2237-43
        }
}
PURPOSE To investigate, over a wide range of cumulative doxorubicin doses, the feasibility of using serum concentrations of cardiac troponin-T (cTnT) as a biomarker for doxorubicin-induced myocardial damage. MATERIALS AND METHODS Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg doxorubicin weekly for 2 to 12 weeks. Cardiomyopathy scores were assessed according to the method of Billingham and serum levels of cTnT were quantified by a noncompetitive immunoassay. Myocardial… CONTINUE READING

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