Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter.

@article{Kaiser2002CorrelationBS,
  title={Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter.},
  author={Rolf W. Kaiser and Bruno Mueller-Oerlinghausen and Diana Filler and Pierre-Benoit Tremblay and Anne Berghoefer and Ivar Roots and J{\"u}rgen Brockm{\"o}ller},
  journal={American journal of medical genetics},
  year={2002},
  volume={114 3},
  pages={323-8}
}
Dysfunctions of the central serotonin (5-hydroxytryptamine, 5-HT) system seem to be associated with psychiatric disorders such as schizophrenia or depression. Previous studies suggested that a 44-bp insertion/deletion polymorphism of the 5-HT transporter (5-HTT) promoter region might influence the transcriptional activity of the 5-HTT gene, and the insertion variant resulted in increased 5-HTT expression and 5-HT uptake. Moreover, a 17-bp variable number of tandem repeat (VNTR) polymorphism of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…