Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes.

@article{WeirichSchwaiger1994CorrelationBS,
  title={Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes.},
  author={Helga Weirich-Schwaiger and Harald G. Weirich and Bernadette E. Gruber and Manfred Schweiger and Monica Hirsch-Kauffmann},
  journal={Mutation research},
  year={1994},
  volume={316 1},
  pages={37-48}
}
Cellular aging appears to be related to and perhaps caused by diminished DNA repair. To elucidate direct correlations between DNA repair capacity and senescence various parameters of cellular aging and DNA repair were studied simultaneously. Of special interest are features of DNA repair and senescence in cultured diploid fibroblasts derived either from healthy young or elderly probands as well as from patients suffering from premature senescence syndromes (Werner syndrome, Cockayne syndrome… CONTINUE READING