Correlation between rates of brain atrophy and cognitive decline in AD.

@article{Fox1999CorrelationBR,
  title={Correlation between rates of brain atrophy and cognitive decline in AD.},
  author={Nick C. Fox and Rachael I. Scahill and William R. Crum and Martin Rossor},
  journal={Neurology},
  year={1999},
  volume={52 8},
  pages={1687-9}
}
Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to… CONTINUE READING

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