Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers.

@article{Costa1997CorrelationBP,
  title={Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers.},
  author={Cleide Costa and G C Trivelato and Anna Maria Pinto and Etelvino Jos{\'e} Henriques Bechara},
  journal={Clinical chemistry},
  year={1997},
  volume={43 7},
  pages={1196-202}
}
5-Aminolevulinic acid (ALA), a heme precursor accumulated in acute intermittent porphyria and lead poisoning, undergoes metal-catalyzed aerobic oxidation at physiological pH to yield reactive free radical species (O2., HO., and ALA.). We analyzed the relationships between plasma ALA concentrations, blood concentrations of lead, protoporphyrin IX (PP-IX), superoxide dismutase (SOD), and methemoglobin (metHb), and urine chemiluminescence (CL) in samples collected from lead-exposed workers. All… CONTINUE READING
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Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid

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