Correlation between particle size, in vivo particle persistence, and lung injury.

  title={Correlation between particle size, in vivo particle persistence, and lung injury.},
  author={G{\"u}nther Oberd{\"o}rster and J F{\'e}rin and Bruce E. Lehnert},
  journal={Environmental Health Perspectives},
  pages={173 - 179}
Dosimetry parameters such as deposition, clearance, retention, and translocation and dissolution of inhaled particles in and to different lung compartments may be important for the persistence of particles in the lung and may correlate with adverse pulmonary effects. We investigated such correlations using a model involving TiO2 particles of two particle sizes (20 nm diameter, ultrafine; 250 nm diameter, fine) of the same crystalline structure (anatase). A 12-week inhalation experiment in rats… CONTINUE READING
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