Correlation between morphology and function in isolated islets of the Zucker rat.

@article{Hayek1979CorrelationBM,
  title={Correlation between morphology and function in isolated islets of the Zucker rat.},
  author={Alberto Hayek and W F Woodside},
  journal={Diabetes},
  year={1979},
  volume={28 6},
  pages={565-9}
}
Obesity in the Zucker rat is accompanied by hyperlipemia, hyperinsulinism, insulin resistance, pancreatic hyperplasia, and islet hypertrophy. This study correlates the morphologic heterogeneity of isolated pancreatic islets with secretion of insulin and glucagon in the perifusion system. Islet size was arbitrarily defined as large (greater than 0.45 mm) or small (smaller than 0.12 mm). Protein content and volume (V = 4/3pir3) were calculated for groups and individual islets, respectively… CONTINUE READING

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