Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers.

@article{Kashiwabara1998CorrelationBM,
  title={Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers.},
  author={Kenji Kashiwabara and Tetsunari Oyama and Takaaki Sano and Toshio Fukuda and Takashi Nakajima},
  journal={International journal of cancer},
  year={1998},
  volume={79 3},
  pages={215-20}
}
In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 expression was observed in 66% of NSCLCs, 80% in squamous cell carcinomas and 46% in adenocarcinomas. An inverse correlation between p16 and Rb expressions was noted. Moreover, the methylation status of… CONTINUE READING