Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale

@inproceedings{Kloeckner2013CorrelationBM,
  title={Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale},
  author={Wolf Kloeckner and Riad Gacem and Tibor Anderlei and Nicole Raven and Stefan Schillberg and Clemens Lattermann and Jochen B{\"u}chs},
  booktitle={Journal of biological engineering},
  year={2013}
}
BackgroundAmong disposable bioreactor systems, cylindrical orbitally shaken bioreactors show important advantages. They provide a well-defined hydrodynamic flow combined with excellent mixing and oxygen transfer for mammalian and plant cell cultivations. Since there is no known universal correlation between the volumetric mass transfer coefficient for oxygen kLa and relevant operating parameters in such bioreactor systems, the aim of this current study is to experimentally determine a universal… CONTINUE READING
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