Correlation between macrolide lung pharmacokinetics and therapeutic efficacy in a mouse model of pneumococcal pneumonia.

Abstract

The correlation between the pharmacokinetics of erythromycin, roxithromycin, clarithromycin, spiramycin and azithromycin and their efficacy was investigated in two pneumococcal pneumonia models. Female Swiss and C57B1/6 mice were infected with Streptococcus pneumoniae strain P4241 by the intratracheal per oral route. This virulent strain produces acute… (More)

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@article{Veber1993CorrelationBM, title={Correlation between macrolide lung pharmacokinetics and therapeutic efficacy in a mouse model of pneumococcal pneumonia.}, author={B. Veber and {\'E}milie Vall{\'e}e and Jean Marie Desmonts and J. J. Pocidalo and Esther Azoulay-Dupuis}, journal={The Journal of antimicrobial chemotherapy}, year={1993}, volume={32 3}, pages={473-82} }