Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma.

@article{Trakhtenbrot2010CorrelationBL,
  title={Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma.},
  author={Luba Trakhtenbrot and Izhar Hardan and Maya Koren-Michowitz and Shirley Oren and Galina Yshoev and Gideon Rechavi and Arnon Nagler and Ninette Amariglio},
  journal={Genes, chromosomes & cancer},
  year={2010},
  volume={49 1},
  pages={
          17-27
        }
}
Multiple myeloma (MM) is a malignancy of the plasma cells (PCs) characterized by a wide variety of genetic and chromosomal abnormalities. In recent years, major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the IGH region on chromosome band 14q32 as a prognostic indicator in MM. In this study we applied a combined cell morphology and FISH method for the analysis of coexistence of t(11;14)(q13;q32) with deletions of the long arm of chromosome… CONTINUE READING

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