Correlation between lipid peroxidation and morphological manifestation of paraquat-induced lung injury in rats

@article{Ogata1990CorrelationBL,
  title={Correlation between lipid peroxidation and morphological manifestation of paraquat-induced lung injury in rats},
  author={Takesaburo Ogata and Sunao Manabe},
  journal={Archives of Toxicology},
  year={1990},
  volume={64},
  pages={7-13}
}
Biochemical and morphological studies of rat lung were performed to determine the role of lipid peroxidation in the in vivo lung toxicity of paraquat. Two injections of 20 mg/kg paraquat were administered intraperitoneally every other day. While notable epithelial damage in the lungs was observed on the day after the second paraquat injection and progressed through the 5th day, the concentration of lipid peroxides in the rat lungs did not increase by the 3rd day after the injection. The lipid… CONTINUE READING
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