Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen.

@article{Peachman2006CorrelationBL,
  title={Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen.},
  author={Kristina K. Peachman and Mangala Rao and Carl R. Alving and Robert Burge and Stephen H Leppla and Venigalla Rao and Gary R Matyas},
  journal={Infection and immunity},
  year={2006},
  volume={74 1},
  pages={794-7}
}
Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain B. anthracis spores. A highly significant correlation was observed between toxin-neutralizing antibody titer and survival after challenge. Future… CONTINUE READING

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Validation of the anthrax lethal toxin neutralization assay

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  • Biologicals
  • 2004
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