Correlation between inertial cavitation dose and endothelial cell damage in vivo.

@article{Hwang2006CorrelationBI,
  title={Correlation between inertial cavitation dose and endothelial cell damage in vivo.},
  author={Joo Ha Hwang and J. K. Tu and Andrew A. Brayman and Thomas J. Matula and Lawrence A. Crum},
  journal={Ultrasound in medicine & biology},
  year={2006},
  volume={32 10},
  pages={1611-9}
}
Previous in vivo studies have demonstrated that vascular endothelial damage can result when vessels containing gas-based microbubble ultrasound contrast agent (UCA) are exposed to MHz-frequency pulsed ultrasound (US) of sufficient pressure amplitudes, presumably as a result of inertial cavitation (IC). The hypothesis guiding this research was that IC is the primary mechanism by which the vascular endothelium (VE) is damaged when a vessel is exposed to pulsed 1-MHz frequency US in the presence… CONTINUE READING