Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1.

@article{Andersen2000CorrelationBI,
  title={Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1.},
  author={Grethe Neumann Andersen and Kenneth Caidahl and Elsadig E Kazzam and A. S. Petersson and Anders Waldenstr{\"o}m and Lucia Mincheva-Nilsson and Solbritt Rantap{\"a}{\"a}-Dahlqvist},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 5},
  pages={1085-93}
}
OBJECTIVE To determine the relationship between vascular function and the inflammatory response in systemic sclerosis (SSc), and to investigate whether production of endothelial-derived nitric oxide (NO) is disturbed in this disease. METHODS We measured plasma nitrate, urinary excretion of both nitrate and cGMP, and soluble adhesion molecules of endothelial origin in patients with SSc and in age- and sex-matched controls and compared these levels between groups. Additionally, we performed… CONTINUE READING

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