Correlation between growth inhibition and intranuclear doxorubicin and 4'-deoxy-4'-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry.

@article{Gigli1989CorrelationBG,
  title={Correlation between growth inhibition and intranuclear doxorubicin and 4'-deoxy-4'-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry.},
  author={M Gigli and T W Rasoanaivo and J. M. Millot and Pierre Jeannesson and Victor Rizzo and Jean Claude Jardillier and Federico Arcamone and Michel Manfait},
  journal={Cancer research},
  year={1989},
  volume={49 3},
  pages={560-4}
}
Intranuclear drug concentration in cells treated with doxorubicin (DXR) or with 4'-deoxy-4'-iododoxorubicin (IDX) was measured by means of a quantitative microspectrofluorometric technique recently developed by us. Resolution of free and bound drug contributions in fluorescence emission spectra, as collected from a microvolume of single living cell nuclei, provided concentration data with about 10% indetermination. Uptake of DXR and IDX into the nucleus of K562 cells and DXR-resistant K562/DXR… CONTINUE READING

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