Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants.

@article{Yongsunthon2007CorrelationBF,
  title={Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants.},
  author={Ruchirej Yongsunthon and Vance G. Fowler and Brian H. Lower and Francis Paul Vellano and Emily H. Alexander and L. Barth Reller and G. Ralph Corey and Stephen Kent Lower},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2007},
  volume={23 5},
  pages={
          2289-92
        }
}
Atomic force microscopy was used to "fish" for binding reactions between a fibronectin-coated probe (i.e., substrate simulating an implant device) and each of 15 different isolates of Staphylococcus aureus obtained from either patients with an infected cardiac prosthesis (invasive group) or healthy human subjects (control group). There is a strong distinction (p = 0.01) in the binding-force signature observed for the invasive versus control populations. This observation suggests that a… 

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