Correlation between experimental human and murine skin sensitization induction thresholds.

  title={Correlation between experimental human and murine skin sensitization induction thresholds.},
  author={Anne Marie Api and David A Basketter and Jon F Lalko},
  journal={Cutaneous and ocular toxicology},
  volume={34 4},
Quantitative risk assessment for skin sensitization is directed towards the determination of levels of exposure to known sensitizing substances that will avoid the induction of contact allergy in humans. A key component of this work is the predictive identification of relative skin sensitizing potency, achieved normally by the measurement of the threshold (the "EC3" value) in the local lymph node assay (LLNA). In an extended series of studies, the accuracy of this murine induction threshold as… CONTINUE READING
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