Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity.

@article{Giraudon1985CorrelationBE,
  title={Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity.},
  author={Pascale Giraudon and T. Fabian Wild},
  journal={Virology},
  year={1985},
  volume={144 1},
  pages={46-58}
}
Measles virus monoclonal antibodies (MoAbs) were used to investigate the structure of the hemagglutinin (H) antigen, in order to study the regions of the molecule implicated in protection. Using a competition binding assay, three overlapping domains were defined, and these have been correlated with the biological activities of their corresponding MoAb. All of the anti-H MoAbs, with a single exception, neutralized virus infectivity in vitro. We investigated their capacity in passive protection… CONTINUE READING