Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.

Abstract

The effect of poly(ADP-ribose) synthesis on chromatin structure was investigated by velocity sedimentation and electron microscopy. We demonstrate that locally relaxed regions can be generated within polynucleosome chains by the activity of their intrinsic poly(ADP-ribose)polymerase. This relaxation phenomenon is also shown to be NAD dependent and to be… (More)

Topics

Cite this paper

@article{Aubin1983CorrelationBE, title={Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.}, author={R J Aubin and Alan Frechette and Gilbert de Murcia and Paul Mandel and A V Lord and Gilles Grondin and Guy G. Poirier}, journal={The EMBO journal}, year={1983}, volume={2 10}, pages={1685-93} }