Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline.

@article{Nslund2000CorrelationBE,
  title={Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline.},
  author={Jan N{\"a}slund and Vahram Haroutunian and Richard C. Mohs and Kenneth L. Davis and Peter Davies and Paul Greengard and Joseph D. Buxbaum},
  journal={JAMA},
  year={2000},
  volume={283 12},
  pages={1571-7}
}
CONTEXT Alzheimer disease (AD) is characterized neuropathologically by the presence of amyloid beta-peptide (Abeta)-containing plaques and neurofibrillary tangles composed of abnormal tau protein. Considerable controversy exists as to whether the extent of accumulation of Abeta correlates with dementia and whether Abeta alterations precede or follow changes in tau. OBJECTIVES To determine whether accumulation of Abeta correlates with the earliest signs of cognitive deterioration and to define… CONTINUE READING
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