Correlation between complete response to anthracycline-based chemotherapy and topoisomerase II-alpha gene amplification and protein overexpression in locally advanced/metastatic breast cancer.

@article{Cardoso2004CorrelationBC,
  title={Correlation between complete response to anthracycline-based chemotherapy and topoisomerase II-alpha gene amplification and protein overexpression in locally advanced/metastatic breast cancer.},
  author={F{\'a}tima Cardoso and Virginie Durbecq and Denis P Larsimont and Marianne Paesmans and J. Y. Leroy and Ghizlane Rouas and Christos Sotiriou and Nathalie Renard and Vincent Richard and Martine J. Piccart and Angelo di Leo},
  journal={International journal of oncology},
  year={2004},
  volume={24 1},
  pages={201-9}
}
UNLABELLED Anthracycline-based regimens are among the most active but also with greater risk of both acute and long-term side effects, namely cardiotoxicity. Predictive markers of response to anthracyclines are therefore essential. Topoisomerase-IIalpha (topo-II) is the target of anthracyclines and preliminary data suggest its promising role as a predictive marker of sensitivity to these drugs. After screening a population of about 350 patients with locally advanced or metastatic breast cancer… CONTINUE READING