Correlation between brain nitric oxide synthase activity and opiate withdrawal

@article{Leza1996CorrelationBB,
  title={Correlation between brain nitric oxide synthase activity and opiate withdrawal},
  author={J. -C. Leza and Ignacio Lizasoain and Beatriz Cu{\'e}llar and Mar{\'i}a {\'A}ngeles Moro and Pedro Lorenzo},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1996},
  volume={353},
  pages={349-354}
}
The opiate withdrawal induced by administration of naloxone to morphine-dependent mice correlates with an increment of calcium- dependent nitric oxide synthase (NOS) activity in the cerebellum. L-NAME, an irreversible competitive inhibitor of NOS (0.5, 5, 25, 50 mg/kg) injected sc. 45 min. prior to naloxone significantly reduced the number of escape jumps and other motor symptoms of abstinence. In addition, L-NAME also decreased NOS activity in cerebellum. L-arginine, but not D-arginine, when… CONTINUE READING

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