Correlation between array-comparative genomic hybridization-defined genomic gains and losses and survival: identification of 1p31-32 deletion as a prognostic factor in myeloma

@article{Chng2010CorrelationBA,
  title={Correlation between array-comparative genomic hybridization-defined genomic gains and losses and survival: identification of 1p31-32 deletion as a prognostic factor in myeloma},
  author={W J Chng and Morie A Gertz and T-H Chung and S A Van Wier and Jonathan J. Keats and Amanda Baker and Peter Leif Bergsagel and John C. Carpten and Rafael Fonseca},
  journal={Leukemia},
  year={2010},
  volume={24},
  pages={833-842}
}
In this study, we correlated array-comparative genomic hybridization-defined abnormalities with survival in two different cohorts of patients treated with therapy based on high-dose melphalan with autologous stem-cell transplantation (64 from the Mayo Clinic and 67 from the University of Arkansas Medical School) and identified that several regions of genomic gains and losses were significantly associated with poorer survival. Three noncontiguous survival relevant regions covering 1p31-33 and… CONTINUE READING