Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.

@article{Cho1997CorrelationBK,
  title={Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.},
  author={Jin-whan Cho and Jee Hyun Kim and Yong Hwan Lee and Kyung Young Chung and Stella K. Kim and Soo Jung Gong and N C You and Hyun Chul Chung and Jae Kyung Roh and Byung Soo Kim},
  journal={Cancer},
  year={1997},
  volume={79 3},
  pages={462-7}
}
BACKGROUND Mutations at codons 12, 13, and 61 of the three ras genes, H-ras, K-ras, and N-ras, convert these genes into active oncogenes. It appears that ras gene mutations can be found in a variety of tumor types. The purpose of this study was to evaluate the clinical significance of K-ras gene mutation in nonsmall cell lung carcinoma (NSCLC). METHODS The authors analyzed 58 NSCLC patients for mutations at codons 12, 13, and 61 of the K-ras gene and correlated the findings with the tumor… CONTINUE READING
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