Correlation between HBV DNA detection by polymerase chain reaction and Pre-S1 antigenemia in symptomatic and asymptomatic hepatitis B virus infections.

@article{Chemin1991CorrelationBH,
  title={Correlation between HBV DNA detection by polymerase chain reaction and Pre-S1 antigenemia in symptomatic and asymptomatic hepatitis B virus infections.},
  author={Isabelle Chemin and I Baginski and Marie Anne Petit and Fabien Zoulim and Christian Pichoud and Francis Capel and Olivier Hantz and Christian Tr{\'e}po},
  journal={Journal of medical virology},
  year={1991},
  volume={33 1},
  pages={51-7}
}
The presence of hepatitis B virus (HBV) genome in sera from 73 symptomatic and asymptomatic HBsAg carriers was studied by the polymerase chain reaction (PCR) with primers specific for the S and C regions. Pre-S proteins of the HBV envelope were detected in serum by a specific monoclonal antibody in a double immunoradiometric assay. Out of twenty-five symptomatic patients with chronic active hepatitis (14 with HBeAg and 11 with anti-HBe), all were positive for HBV DNA by PCR, while 14/14 HBeAg… CONTINUE READING

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