Correlation between Genetic and Geographic Structure in Europe

@article{Lao2008CorrelationBG,
  title={Correlation between Genetic and Geographic Structure in Europe},
  author={Oscar Lao and Timothy Lu and Michael Nothnagel and Olaf Junge and Sandra Freitag-Wolf and Amke Caliebe and Miroslava Bala{\vs}{\vc}{\'a}kov{\'a} and Jaume Bertranpetit and Laurence A. Bindoff and David Comas and Gunilla Holmlund and Anastasia Kouvatsi and Milan Macek and Isabelle Mollet and Walther Parson and Jukka U. Palo and Rafał Płoski and Antti Sajantila and Adriano Tagliabracci and Ulrik Gether and Thomas M. Werge and Fernando Rivadeneira and Albert Hofman and Andr{\'e} G. Uitterlinden and Christian Gieger and Heinz-Erich Wichmann and Andreas R{\"u}ther and Stefan Schreiber and Christian F. W. Becker and Peter J. N{\"u}rnberg and Matthew R. Nelson and Michael Krawczak and Manfred Kayser},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1241-1248}
}
View on Elsevier
cell.com
474 Citations
Highly Influential Citations
27
Background Citations
142
Methods Citations
32
Results Citations
33

Figures and Tables from this paper

474 Citations

An Overview of the Genetic Structure within the Italian Population from Genome-Wide Data
TLDR
It is shown that the current population of Sardinia can be clearly differentiated genetically from mainland Italy and Sicily, and that a certain degree of genetic differentiation is detectable within the current Italian peninsula population.
Genes mirror geography within Europe
TLDR
Despite low average levels of genetic differentiation among Europeans, there is a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans.
Genetic markers and population history: Finland revisited
TLDR
It is suggested that the expression of ‘Finnish Disease Heritage’ illnesses, more common in the eastern/north-eastern Finland, stems from long-term drift, rather than from relatively recent founder effects.
Population genetics: Genetic geography
TLDR
New insights are given into European population history and, from a practical point of view, show how important it is to consider population structure to avoid false positives when interpreting genomewide association data.
The Genetic Structure of the Swedish Population
TLDR
It is shown that genetic differences within a single country may be substantial, even when viewed on a European scale, and population stratification needs to be accounted for, even within a country like Sweden, which is often perceived to be relatively homogenous.
Genetic Structure of Europeans: A View from the North–East
TLDR
This analysis revealed that the genetic structure of the European population correlates closely with geography, and allows the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS).
The place of metropolitan France in the European genomic landscape
TLDR
It is found that French Basques, already known for their linguistic uniqueness, are genetically distinct from all other groups and that the populations from southwest France (namely the Gascony region) share a large proportion of their ancestry with Basques.
Genomic and geographic distribution of SNP-defined runs of homozygosity in Europeans.
TLDR
The data show that the genomic identity-by-descent patterns of Europeans are also clinal, consistent with a larger effective population size in Southern than in Northern Europe, combined with a higher historic population density and mobility.
Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe
TLDR
The data suggest a small eastern contribution among the Finns, consistent with the historical and linguistic background of the population, and illustrate that population history is often important for patterns of genetic variation, and that the analysis of hundreds of thousands of SNPs provides high resolution also for population genetics.
Genetic Structure of the Spanish Population
TLDR
In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure, although patterns of micro-structure may be able to predict locations of origin from distant regions.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
European Population Substructure: Clustering of Northern and Southern Populations
TLDR
Using a genome-wide single nucleotide polymorphism (SNP) panel, population structure in a diverse group of Europeans and European Americans was observed, with a consistent and reproducible distinction between “northern” and “southern" European population groups.
Geographic patterns of mtDNA diversity in Europe.
TLDR
The distribution of the zones of highest mitochondrial variation (genetic boundaries) confirmed that the Saami are sharply differentiated from an otherwise rather homogeneous set of European samples, and an area of significant clinal variation was identified around the Mediterranean Sea (and not in the north), even though the differences between northern and southern populations were insignificant.
Measuring European population stratification with microarray genotype data.
TLDR
The results reveal the presence of several significant axes of stratification, most prominently in a northern-southeastern trend, but also along an east-west axis.
Analysis and Application of European Genetic Substructure Using 300 K SNP Information
TLDR
Two sets of European substructure ancestry informative markers (ESAIMs) were identified that provide substantial substructure information that can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans.
Spatial patterns of human gene frequencies in Europe.
TLDR
The majority of patterns are patchy, consistent with hypotheses of isolation by distance or of settlement of genetically differing, subsequently expanding ethnic groups, but some clinal patterns reported here support the Neolithic demic-expansion hypothesis, others suggest latitudinal selection.
Origins and evolution of the Europeans' genome: evidence from multiple microsatellite loci
TLDR
This work estimated admixture rates in European populations from data on 377 autosomal microsatellite loci in 235 individuals, using five different numerical methods, and showed a strong and significant negative correlation with distance from the Near East.
Signature of recent historical events in the European Y-chromosomal STR haplotype distribution
TLDR
It is concluded that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history.
Discerning the Ancestry of European Americans in Genetic Association Studies
TLDR
Empirical patterns of population structure in European Americans are investigated, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure.
Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysis
TLDR
The data are consistent with the assumption of homogeneity of present-day paternal lineages within Poland and their distinctiveness from other parts of Europe, at least in respect to their Y-STR haplotypes.
Significant genetic differentiation between Poland and Germany follows present-day political borders, as revealed by Y-chromosome analysis
TLDR
It is suggested here that the pronounced population differentiation between the two geographically neighbouring countries, Poland and Germany, is the consequence of very recent events in human population history, namely the forced human resettlement of many millions of Germans and Poles during and, especially, shortly after World War II.
...
...