Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.

@article{Chen2014CorrelationBD,
  title={Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.},
  author={Chao Chen and Chunling Zhang and Lijun Cheng and James Reilly and Jeffrey R. Bishop and John A. Sweeney and Hua-yun Chen and Elliot S. Gershon and Chunyu Liu},
  journal={Bipolar disorders},
  year={2014},
  volume={16 8},
  pages={790-9}
}
OBJECTIVES Aberrant DNA methylation and gene expression have been reported in postmortem brain tissues of psychotic patients, but until now there has been no systematic evaluation of synergistic changes in methylation and expression on a genome-wide scale in brain tissue. METHODS In this study, genome-wide methylation and expression analyses were performed on cerebellum samples from 39 patients with schizophrenia, 36 patients with bipolar disorder, and 43 unaffected controls, to screen for a… CONTINUE READING
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