Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population.

@article{Gotoh2008CorrelationBC,
  title={Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population.},
  author={Norimoto Gotoh and Ryo Yamada and Hideo Nakanishi and Masaaki Saito and Tomohiro Iida and Fumihiko Matsuda and Nagahisa Yoshimura},
  journal={Clinical & experimental ophthalmology},
  year={2008},
  volume={36 5},
  pages={437-42}
}
BACKGROUND Typical exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are two of the major macular diseases found in Asians. Although genomic studies have shown a contribution by CFH and LOC387715/HTRA1 polymorphisms to the development of these two diseases, the correlation of the clinical phenotypes to these genotypes has not been determined in Asian patients. METHODS The prevalence of the CFH Y402H and HTRA1 rs11200638 genotypes was determined in… CONTINUE READING