Correlation between BRCA1 and TopBP1 protein expression and clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

Abstract

To investigate the correlation between protein expression of breast cancer susceptibility gene 1 (BRCA1) and topoisomerase IIβ-binding protein 1 (TopBP1) and clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy. Immunohistochemical staining was conducted to detect the protein expression of BRCA1 and TopBP1 in 101 cases of… (More)
DOI: 10.1007/s00280-015-2773-0

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