Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines

@article{Denoyer2005CorrelationB9,
  title={Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines},
  author={Delphine Denoyer and Nathalie Perek and Nathalie Le Jeune and J. Cornillon and Francis Dubois},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2005},
  volume={32},
  pages={820-827}
}
Although a number of prognostic indicators have been developed, it is still difficult to predict the biological behaviour of all cancer types. 99mTc-(V)-DMSA (V DMSA) uptake and focal adhesion kinase (FAK) expression and activation level could be potential agents for this purpose. We hypothesised the existence of a correlation between V DMSA, whose uptake is linked to phosphate ions, essential compounds for tumour growth and cell proliferation, and the adhesion protein FAK, whose elevated… CONTINUE READING