Correlation Between Tumor Necrosis Factor Alpha and Proteinuria in Type-2 Diabetic Patients

@article{Refat2010CorrelationBT,
  title={Correlation Between Tumor Necrosis Factor Alpha and Proteinuria in Type-2 Diabetic Patients},
  author={Hassan Refat and G M{\'a}dy and Mma El Ghany and Khaled Abou Seif and Es El Hadidi and Yasser El-shahawy and Dawlat Hussein Sany and Hea El Aziz},
  journal={Arab journal of nephrology and transplantation},
  year={2010},
  volume={3},
  pages={33-38}
}
Introduction: Diabetic Nephropathy (DN) is the single most common cause of end stage renal disease (ESRD) in many countries. Inflammation is a potential factor in the development and progression of DN and recent data indicate that diabetes includes an inflammatory component which may contribute to diabetic complications. Methods: This study was conducted at Ain Shams University Hospital on 95 patients with type-2 diabetes mellitus complicated with retinopathy and fifteen age- and sex-matched… 
View via Publisher
ajol.info
6 Citations
Background Citations
2

Figures and Tables from this paper

6 Citations

Urinary Level of Tumor Necrosis Factor Alpha in Patients with Type –2 Diabetic Nephropathy

Investigation of possible correlation between the presence and degree of albuminuria and urinary tumor necrosis factor-alpha as a marker of inflammation in diabetic nephropathy in type 2 diabetes mellitus suggests that TNF-α play a significant role in the pathogenesis and progression of renal injury in diabetes.

Levels of serum vaspin and tumor necrosis factor-α in patients with type 2 diabetes mellitus in relation to kidney function and glycemic control

Strict monitoring of T2DM can reduce the morbidity and mortality rate and will also improve the quality of life of diabetic patients, and significant correlations of vaspin and TNF were found with age of T1DM patients, hypertension, BMI, and lipid profile, but not with HbA1c.

Correlation of spot urine protein-creatinine ratio with 24-hour urinary protein in type 2 diabetes mellitus patients: A cross sectional study

The random urine P:C ratio predicts the amount of 24-hour urinary protein excretion with high accuracy and can be used as a faster diagnostic substitute for 24- hour urinary protein estimation.

To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of proteinuria

Urine protein creatinine ratio can be used as a faster diagnostic substitute for 24 hr urine protein estimation in the screening and evaluation of diabetic nephropathy.

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

Significant changes in the markers of the oxidative state with increased NO and 8-OHdG, as well as a significant decrease in the antioxidant defenses SOD, GPx, and in the DNA repair enzyme in living renal donors after 6 months of follow-up are found.

Diagnostic utility of protein to creatinine ratio (P/C ratio) in spot urine sample within routine clinical practice

The literature review indicates the usefulness of the spot P/C ratio in various disease states; therefore, this test should be available in every laboratory.

References

SHOWING 1-10 OF 19 REFERENCES

Urinary tumour necrosis factor-alpha excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients.

  • J. NavarroC. MoraM. MurosJavier García
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2006
In patients with type 2 diabetes, urinary TNFalpha excretion is elevated and correlates with severity of renal disease in terms of both glomerular and tubulointerstitial damage, suggesting a significant role for TNF alpha in the pathogenesis and progression of renal injury in diabetes mellitus.

Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus.

Tumor necrosis factor-alpha gene expression in diabetic nephropathy: relationship with urinary albumin excretion and effect of angiotensin-converting enzyme inhibition.

Data provide a novel insight into the pathogenic mechanisms of DN, and support the hypothesis that inflammatory mechanisms may play a significant role in the development and progression of renal injury secondary to diabetes mellitus.

The role of TNF-α in diabetic nephropathy: Pathogenic and therapeutic implications

The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications.

The role of TNF-alpha as a pathogenic factor in renal injury, focusing on diabetic nephropathy, is discussed, and potential treatment strategies based on modulation of T NF-alpha activity are described.

The significance of tumor necrosis factor-alpha in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment.

Tumor necrosis factor-α gene expression in diabetic nephropathy: Relationship with urinary albumin excretion and effect of angiotensin-converting enzyme inhibition

Data provide a novel insight into the pathogenic mechanisms of DN, and support the hypothesis that inflammatory mechanisms may play a significant role in the development and progression of renal injury secondary to diabetes mellitus.

Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy.

The results suggest that serum levels of IL-18, TNF-alpha, and IL-6 may have some etiopathogenic roles in diabetic nephropathy.

Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy.

Aminoguanidine treatment significantly decreased the accumulation of advanced glycation end-products (AGEs) in GBM of diabetic rats, suggesting that AGE-proteins may be involved in the production of TNF and IL-1 from M phi.

Genetic Determination of TNF and Myeloperoxidase Production in Dialyzed Patients with Diabetic Nephropathy

In diabetic nephropathy patients molecular variants of TNF are more frequent than in nondiabetic patients with chronic renal failure and these changes might be associated with altered ability to TNF synthesis.