Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line

@article{Grs1998CorrelationBO,
  title={Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line},
  author={Marie-Catherine Gr{\`e}s and Bernard Julian and Martine Bourri{\'e} and Viviane Meunier and Claude Roques and Marion Berger and Xavier Boulenc and Yves Berger and G{\'e}rard Fabre},
  journal={Pharmaceutical Research},
  year={1998},
  volume={15},
  pages={726-733}
}
Purpose. To determine and compare the relationship between in vivo oral absorption in humans and the apparent permeability coefficients (P app ) obtained in vitro on two human intestinal epithelial cell lines, the parental Caco-2 and the TC-7 clone. Methods. Both cell lines were grown for 5−35 days on tissue culture-treated inserts. Cell monolayers were analysed for their morphology by transmission electron micrography, and for their integrity with respect to transepithelial electrical… CONTINUE READING

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Both cell lines were grown for 5−35 days on tissue culture - treated inserts .
P app were determined for 20 compounds exhibiting large differences in chemical structure , molecular weight , transport mechanisms , and percentage of absorption in humans .
P app were determined for 20 compounds exhibiting large differences in chemical structure , molecular weight , transport mechanisms , and percentage of absorption in humans .
Both cell lines were grown for 5−35 days on tissue culture - treated inserts .
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