Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in Rats

@article{Teunissen2004CorrelationBI,
  title={Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in Rats},
  author={M. W. Teunissen and I. Brorens and H. J. De Langen and Anne M. Geerlings and D. Breimer},
  journal={Pharmaceutical Research},
  year={2004},
  volume={3},
  pages={156-161}
}
  • M. W. Teunissen, I. Brorens, +2 authors D. Breimer
  • Published 2004
  • Chemistry, Medicine
  • Pharmaceutical Research
  • Two model substrates for oxidative hepatic enzyme activity, viz. antipyrine (A) and theophylline (T), were given simultaneously to rats by iv administration. Blood concentrations of A and T were measured by a high-performance liquid chromatographic (HPLC) method. Urinary excretions of A, T, and the major metabolites arising from A—4-hydroxyantipyrine (OHA), norantipyrine (NORA), 3-hydroxymethylantipyrine (HMA), and 4,4′-dihydroxyantipyrine (DOHA)—and from T—1-methyluric acid (1-MU) and 1,3… CONTINUE READING

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