Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption.

@article{Hou2016CorrelatingTE,
  title={Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption.},
  author={Jue Hou and Heather J. Wright and Nicole Chan and Richard Quang-Anh Tran and Olga V Razorenova and Eric O. Potma and Bruce J. Tromberg},
  journal={Journal of biomedical optics},
  year={2016},
  volume={21 6},
  pages={
          60503
        }
}
  • Jue Hou, Heather J. Wright, +4 authors Bruce J. Tromberg
  • Published in Journal of biomedical optics 2016
  • Medicine
  • Two-photon excited fluorescence (TPEF) imaging of the cellular cofactors nicotinamide adenine dinucleotide and oxidized flavin adenine dinucleotide is widely used to measure cellular metabolism, both in normal and pathological cells and tissues. When dual-wavelength excitation is used, ratiometric TPEF imaging of the intrinsic cofactor fluorescence provides a metabolic index of cells—the “optical redox ratio” (ORR). With increased interest in understanding and controlling cellular metabolism in… CONTINUE READING

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